Non-meiotic chromosome instability in human immature oocytes
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چکیده
منابع مشابه
I-14: Vitrification of Human Immature Oocytes in IVM Program
The cryopreservation of immature GV oocytes by vitrification is offering attractive perspectives, since they represent an important pool of germ cells for women undergoing IVM cycles, or at risk of infertility for OHSS or PCOs, particularly those poor responders to gonadotropin stimulation, or in case of cancer. Therefore, it becomes necessary to optimize both cryopreservation technique as well...
متن کاملMeiotic Recombination in Human Oocytes
Studies of human trisomies indicate a remarkable relationship between abnormal meiotic recombination and subsequent nondisjunction at maternal meiosis I or II. Specifically, failure to recombine or recombination events located either too near to or too far from the centromere have been linked to the origin of human trisomies. It should be possible to identify these abnormal crossover configurat...
متن کاملMeiotic spindle assembly and chromosome segregation in oocytes
611 The Rockefeller University Press $30.00 J. Cell Biol. Vol. 215 No. 5 611–619 https://doi.org/10.1083/jcb.201607062 Introduction Sexual reproduction relies on the fusion of paternal and maternal haploid gametes—the sperm and the extremely large oocyte, respectively—forming a new diploid organism. Meiotic divisions contribute solely to the formation of haploid gametes. They consist of two suc...
متن کاملMeiotic spindle assembly and chromosome segregation in oocytes
Oocytes accumulate maternal stores (proteins, mRNAs, metabolites, etc.) during their growth in the ovary to support development after fertilization. To preserve this cytoplasmic maternal inheritance, they accomplish the difficult task of partitioning their cytoplasm unequally while dividing their chromosomes equally. Added to this complexity, most oocytes, for reasons still speculative, lack th...
متن کاملEffects of cilostamide and forskolin on the meiotic resumption and embryonic development of immature human oocytes.
BACKGROUND In an attempt to allow for acquisition of oocyte cytoplasmic maturation, PDE3 specific inhibitor, cilostamide and adenylate cyclase activator, forskolin were used to extend pre-maturation culture of immature human oocytes. METHODS Cumulus-oocyte complexes retrieved from unstimulated ovaries were continuously cultured under 20 microM cilostamide or 50 microM forskolin, alone or in c...
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ژورنال
عنوان ژورنال: European Journal of Human Genetics
سال: 2013
ISSN: 1018-4813,1476-5438
DOI: 10.1038/ejhg.2013.106